Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Long-Term Stability of the Elemental Composition in Biological Materials.
Author Zeisler, R. ; Greenberg, R. ; Stone, S. ; Sullivan, T. ;
CORP Author National Bureau of Standards (NML), Gaithersburg, MD. Inorganic Analytical Research Div.;Environmental Protection Agency, Washington, DC.
Publisher 1988
Year Published 1988
Stock Number PB89-156939
Additional Subjects Chemical analysis ; Biological surveys ; Tissue extracts ; Standards ; Concentration(Composition) ; Chemical stabilization ; Neutron activation analysis ; Zinc ; Selenicum ; Arsenic ; Trace elements ; Liver extracts ; Reprints ; Standard reference materials
Library Call Number Additional Info Location Last
NTIS  PB89-156939 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/08/1989
Collation 4p
Lyophilized and radiation sterilized biological certified reference materials (CRMs) are believed to be stable in their chemical composition. Generally, the certifying agencies consider the certificates of these biological CRMs valid for a 5-year shelf life, i.e., apart from measurable moisture content, the chemical composition should not change during that time. The long-term behavior of fresh frozen material is not known. In the study the elemental compositions of the Bovine Liver Standard Reference Material (SRM 1577) and human liver tissue samples are evaluated over a time period of more than 7 years. The concentrations of selected elements were determined by neutron activation analysis at various times. The initial evaluation of zinc, selenium and arsenic results gives no indication of changes during 7 years storage of fresh frozen tissues, however, a trend towards lower arsenic concentrations has been observed in SRM 1577 during a 10-year period.