Record Display for the EPA National Library Catalog
RECORD NUMBER: 137 OF 689
|OLS Field Name||OLS Field Data|
|Main Title||Chemical Reactivity, Cytotoxicity, and Mutagenicity of Chloropropanones.|
|Author||Merrick, B. A. ; Smallwood, C. L. ; Meier, J. R. ; McKean, D. L. ; Kaylor, W. H. ;|
|CORP Author||Health Effects Research Lab., Research Triangle Park, NC.|
|Additional Subjects||Chemical reactions ; Toxicity ; Chlorine organic compounds ; Rats ; Water treatment ; Laboratory animals ; In vitro analysis ; Cytology ; Disinfection ; Mutagens ; Carcinogens ; Chlorination ; Disinfection ; Salmonella ; Biodeterioration ; Humans ; Exposure ; Concentration(Composition) ; pH ; Metabolism ; Reprints ; Chloropropanones ; Haloketones ; Propanone/dichloro ; Propanone/monochloro|
Studies were conducted to assess the in vitro toxicity of three chloropropanones: monochloropropanone (MCP), 1,1-dichloropropanone (1,1-DCP) and 1,3-dichloropropanone (1,3-DCP). Chloropropanones reacted directly with reduced glutathione in sodium phosphate buffer at pH 7.4. All chloropropanones were cytotoxic to suspensions of male, rat hepatocytes in a concentration range of 0.5-10 mM. Cytotoxicity was preceded by rapid decline in cellular GSH levels. Mutagenic potencies among the chloropropanes in Salmonella typhimurium bacteria differed greatly. 1,3-DCP was mutagenic in the nmole range, 1,1-DCP was weakly mutagenic in the micromole range and MCP was not mutagenic. Mutagenicity of the dichloropropanones was evident without metabolic activation.