||Approach to Identifying Specialized Batteries of Bioassays for Specific Classes of Chemicals: Class Analysis Using Mutagenicity and Carcinogenicity Relationships and Phylogenetic Concordance and Discordance Patterns. 1. Composition and Analysis of the Overall Data Base. A Report of Phase 2 of the U.S. Environmental Protection Agency Gene-Tox Program.
Ray, V. A. ;
Kier, L. D. ;
Kannan, K. L. ;
Haas, R. T. ;
Auletta, A. E. ;
||Health Effects Research Lab., Research Triangle Park, NC. ;Pfizer Central Research, Groton, CT. ;Monsanto Co., St. Louis, MO. ;Oak Ridge National Lab., TN.
Chemical analysis ;
Data processing ;
Chemical compounds ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
The major utility and/or benefit of this compilation will be derived from a chemical class by chemical class comparative analysis of individual assay performance. The data base will serve as a resource for hazard evaluation of chemicals through structural correlations and biological end points and associated end points such as carcinogenicity. An example analysis is presented using chemical Class 5 (alkyl sulfates sulfoxides, sulfones, sulfonates, organic sulfur compounds not otherwise classified) and includes the four components. (Copyright (c) Elsevier Science Publishers B.V. (Biomedical Division).)