Record Display for the EPA National Library Catalog

RECORD NUMBER: 95 OF 1643

OLS Field Name OLS Field Data
Main Title Application of Pharmacokinetic Models to Predict Target Dose (Chapter 2).
Author Blancato, J. N. ; Bishoff, K. B. ;
CORP Author Environmental Monitoring Systems Lab., Las Vegas, NV. ;Delaware Univ., Newark.
Publisher 1994
Year Published 1994
Report Number EPA/600/A-94/134;
Stock Number PB94-190345
Additional Subjects Pharmacokinetics ; Models ; Risk assessment ; Public health ; Pharmacology ; Dosage ; Health risks ; Physiology ; Chemical compounds ; Flow distribution ; Metabolism ; Toxicity ; Research and development ; Membranes ; Environmental monitoring ; Reprints ; Micropharmacokinetic models
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB94-190345 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 11/11/1994
Collation 20p
Abstract
The number of new and old chemical compounds to which the human race is exposed has quickly become astronomical. Methods of risk assessment have been slow to develop. Industry, government and academia have had to scrupulously examine the benefits-to-cost ratio of these studies. The limiting factors appear to be the questions of extrapolation and the compatibility of different metabolic processes in different species. The chapter discusses (1) pharmacokinetics, (2) model development, (3) flow-limited assumptions, (4) membrane-limited assumption, (5) micropharmacokinetic physiologic models and their implementation.