Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Study of the Effects of Nitrilotriacetic Acid on Mammalian Liver and Intestinal Enzymes.
Author Pringle, Benjamin H. ; Zygmuntowicz, Aniela S. ; McWeeney, Susan E. ; Lancellotti., Kenneth A. ;
CORP Author Environmental Protection Agency, Washington, D.C.
Year Published 1971
Stock Number PB-256 354
Additional Subjects Liver ; Enzymes ; Toxicology ; Biochemistry ; Intestines ; Mammals ; Metabolism ; Ingestion(Biology) ; Mice ; Bioassay ; Chelating agents ; Chemical compounds ; Microsomes ; Acetic acid/nitrilo-tri
Library Call Number Additional Info Location Last
NTIS  PB-256 354 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 30p
Chemical compounds foreign to mammalian liver stimulate the hepatic microsomal system to increased, but nonspecific, enzymatic activity. The stimulatory effect on liver enzymes being non-specific, increased hepatic activity results also in an accelerated metabolism of normal body constituents and a more rapid rate of utilization of administered drugs. One substance, nitrilotriacetic acid, an effective chelating agent used as a partial substitute for phosphate in detergents, has not been thoroughly tested for metabolic effects on mammalian microsomal systems. Should undegraded NTA be discharged into the environment in sizable amounts and concentrate in potable water supplies, cumulative exposures of man to the chemical could result in chronic illness or debilitating physiological states. In an attempt to evaluate the metabolic effects of this foreign substance on mammalian systems, the authors have studied several enzymes in the liver and intestine of mice subjected to chronic oral administration of the sodium salt of nitrilotriacetic acid in drinking water at a concentration ten times the expected environmental level.