Record Display for the EPA National Library Catalog

RECORD NUMBER: 35 OF 65

OLS Field Name OLS Field Data
Main Title Insect Virus: Assays for Toxic Effects and Transformation Potential in Mammalian Cells.
Author Hartig, P. C. ; Chapman, M. A. ; Hatch, G. G. ; Kawanishi., C. Y. ;
CORP Author Northrop Services, Inc./Environmental Sciences, Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1989
Year Published 1989
Report Number EPA-68-02-4450; EPA/600/J-89/221;
Stock Number PB90-146093
Additional Subjects Toxicity ; Viruses ; Insects ; Mammals ; Cells(Biology) ; Pesticides ; Exposure ; Tables(Data) ; Bioassay ; In vitro analysis ; Sensitivity ; Reproducibility ; Reprints ; Autographa californica ; Viral cell transformation ; Biological pest control ; Dose-response relationships ; Cell survival
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB90-146093 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/15/1990
Collation 7p
Abstract
The increased sensitivity and reproducibility of two new assays developed for inclusion in Subdivision M of the Pesticide Assessment Guidelines are demonstrated. The IRS assay for toxicity and SHE/SA7 transformation assay were utilized together with presently recommended mammalian cell culture tests on a candidate viral pesticide. The results show that the IRS assay was capable of showing the cytotoxicity of the pesticidal agent in more different human cell lines and at lower dosages than the presently prescribed tests. The SHE/SA7 assay had significantly lower spontaneous transformation levels than the Balb/c 3T3 test. (Copyright (c) 1989, American Society for Microbiology.)