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RECORD NUMBER: 34 OF 65

OLS Field Name OLS Field Data
Main Title Initial Submission: 24-Hour Exposure Clonal Syrian Golden Hamster Embryo (SHE) Cell Transformation Assay using Ortho-Toluidine with Cover Letter dated 04/30/1996.
CORP Author Proctor and Gamble Co., Cincinnati, OH. Ivorydale Technical Center.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1996
Report Number 8EHQ-0596-13643
Stock Number OTS0558517
Additional Subjects Toxicology ; Health effects ; Toxic substances ; Ortho-toluidine ; Chronic toxicity ; Cell transformation ; Mammals ; Hamsters ; In vitro ; CAS No 636-21-5
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Status
NTIS  OTS0558517 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 05/12/2010
Collation 49p
Abstract
A 24 hour exposure SHE cell transformation assay was performed to test the morphological transformation potential of ortho-Toluidine. The assay was performed according to the methodology outlined in the attached protocol. In the 24 hour SHE assay ortho-Toluidine gave significant (p<0.05) morphologicd transformation results, relative to the solvent control, at 4 of 5 tested concentrations. The trend test result for this assay was also significantly positive. According to our established criteria which states that either two positive doses or one positive dose and a positive trend test constitutes a positive SHE cell transformation assay result, ortho-Toluidine is considered positive in the 24 hour exposure SHE cell transformation assay.