Record Display for the EPA National Library Catalog

RECORD NUMBER: 14 OF 21

OLS Field Name OLS Field Data
Main Title Initial Submission: Letter from Phillips Petroleum Co. to USEPA re: Skin Corrosion/Primary Skin Irritation and Primary Eye Irritation Studies on Rabbit, with Attachments (Study Reports) and dated 02/26/1999.
CORP Author Phillips Petroleum Co., Bartlesville, OK.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1999
Report Number FYI-OTS-0399-1352
Stock Number OTS0001352
Additional Subjects Toxicology ; Health effects ; PPCO-M Catalyst Lorex No X-96-4 ; Acute toxicity ; Primary skin irritation ; Primary eye irritation ; Mammals ; Rabbits ; CAS No 82626-48-0
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Status
NTIS  OTS0001352 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 09/09/2010
Collation 39p
Abstract
Three healthy, young adult New Zealand White rabbits (2 male, 1 female) were the experimental animals. Just prior to dosing, a local anesthetic was placed in both eyes of each rabbit. Undiluted PPCO-M Catalyst at a dose of 0.1 mg was instilled into the conjunctival sac of the right eye. The eyelids were then gently held closed for approximately 1 second then released. The left eye served as a control for each rabbit and was treated in a manner identical to the right eye, except no test material was administered. The grades of ocular reaction were recorded at 1, 24, 48 and 72 hours after treatment. The corneas of all treated eyes were examined immediately after the 24-hour observation with a fluorescein sodium ophthalmic solution. Any corneas that exhibited fluorescein staining were reexamined with fluorescein at each consecutive observation. All treated eyes were washed with room temperature deionized water for one minute immediately after recording of the 24-hour observation. The eyes were scored using a slightly modified method of Draize* and Kay and Calandra.