||Reduction of Microsomial Phospholipids in Experimental Cardiac Discompensation. (Heart-Lung of Rat Preparation).
Panagia, V. ;
Minelli, R. ;
Zonta., F. ;
||Environmental Protection Agency, Research Triangle Park, N.C. Translation Services Section.
Cardiovascular diseases ;
In vitro analysis ;
Experimental data ;
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Because previous results had shown that experimental heart failure was not caused by reduction of oxidable substrate and high-energy phosphate content in myocardial tissue, further experiments have been performed in order to see if any alteration in subcellular membranes, which are strictly involved in the excitation-contraction coupling mechanism, could be detected in failing heart. Experimental cardiac failure was realized by imposing a high load on the left ventricle of the rat heart-lung preparation. The determination of mitochondrial and microsomal phospholipid classes has shown: (1) no change in mitochondrial phospholipids and (2) a 20% reduction in phosphatidylcholine, 35% in phosphatidylserine and 34% in sphingomyelin in the microsomal fraction from failed heart.