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RECORD NUMBER: 312 OF 313

OLS Field Name OLS Field Data
Main Title Utility of short-term tests for genetic toxicity /
Author DeMarini, D. M. ; Lewtas, J. ; Brockman, H. E.
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Genetic Bioassay Branch. ;Illinois State Univ., Normal. Dept. of Biological Sciences.
Publisher U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory,
Year Published 1989
Report Number EPA/600/D-89/061
Stock Number PB89-223622
Additional Subjects Toxicity ; Hazardous materials ; Carcinogens ; Rodents ; Mutagens ; Mutagenicity tests ; Carcinogenicity tests ; Environmental pollution
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB89-223622 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 01/01/1988
Collation 24 pages ; 28 cm
Abstract
By definition, short-term tests (STTs) for genetic toxicity detect genotoxic agents, not carcinogens specifically. However, there is sufficient evidence, based on mechanistic considerations alone, to say that genotoxic agents are potential carcinogens. STTs have high statistical power, are almost always replicated, can be performed rather easily under various sets of experimental conditions, are relatively inexpensive, and detect a variety of endpoints relevant to carcinogenesis. In addition, several STTs have shown considerable utility in evaluating the genotoxic effects of real-world, environmental complex mixtures as well as the antimutagenic effects of various pure compounds and complex mixtures. STTs are likely to continue to be refined, resulting in STTs that are increasingly more relevant to human mutation and disease. Their utility should not be judged solely against the questionable standard of a rodent carcinogenicity assay.
Notes
EPA/600/D-89/061. PB89-223622. Microfiche.