Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Inhalation Teratology Studies of Captan and Folpet in Mice.
Author Courtney, K. D. ; Andrews, J. E. ; Stevens, J. T. ; Farmer, J. D. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1983
Report Number EPA-600/1-83-017;
Stock Number PB84-128099
Additional Subjects Toxicology ; Pesticides ; Fungicides ; Mice ; Laboratory animals ; Exposure ; Chlorine organic compounds ; Dosage ; Concentration(Composition) ; Nitrogen organic compounds ; Folpet ; Captan ; Cyclohexane dicarboximide/N-((trichloromethyl)thio) ; Teratogenesis ; Phthalimide/N-((trichloromethyl)-thio)
Library Call Number Additional Info Location Last
NTIS  PB84-128099 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 20p
Timed pregnant CD-1 mice were exposed to captan or folpet by the intragastric, subcutaneous or inhalation route. A dose of 100 mg/kg/day of captan or folpet was administered subcutaneously or intragastrically from day 6-15 of gestation. The dose levels for the inhalation route were averaged from daily exposure levels determined by monitoring the chambers. The inhalation route provided daily average concentrations approximating 491 mg/hr/cu. m. for captan and 624 mg/hr/cu. m. for folpet, four hr/day from the 6th to the 13th day of gestation. The particle size was less than 5 micrometers. There was approximately 10% material mortality with both captan and folpet by the inhalation route, while no mortality was seen by the other two routes. The only fetal toxicity noted was a reduction in fetal body weight in the group administered captan subcutaneously. Neither captan or folpet were teratogenic in CD-1 mice exposed by the subcutaneous, oral or inhalation routes.