Record Display for the EPA National Library Catalog

RECORD NUMBER: 44 OF 1030

OLS Field Name OLS Field Data
Main Title Alpha-2u-globulin : association with chemically induced renal toxicity and neoplasia in the male rat /
Author Baetcke, K. P. ; Hard, G. C. ; Rodgers, I. S. ; McGaughy, R. E. ; Tahan, L. M. ; Baetcke, Karl P.
Other Authors
Author Title of a Work
Baetcke, Karl.
CORP Author Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.
Publisher U.S. Environmental Protection Agency,
Year Published 1991
Report Number EPA/625/3-91/019F; OHEA-F-385
Stock Number PB92-143668
OCLC Number 24842709
Subjects Risk assessment. ; Alpha globulins. ; Toxicity ; Kidney ; Kidney neoplasms ; Rats ; Carcinogens ; Males ; Kidney diseases ; Dose-response relationships ; Species specificity ; Alpha 2-microglobulins ; Kidney disease--Diagnosis ; Cancer--Diagnosis ; Environmentally induced diseases
Additional Subjects Toxicity ; Kidney ; Kidney neoplasms ; Rats ; Carcinogens ; Males ; Risk assessment ; Kidney diseases ; Dose-response relationships ; Species specificity ; Alpha 2-microglobulins
Internet Access
Description Access URL
http://nepis.epa.gov/Exe/ZyPDF.cgi?Dockey=3000480X.PDF
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
EHAM  RA427.3.A456 1991 Region 1 Library/Boston,MA 04/29/2016
EJAD  EPA 625/3-91-019F Region 3 Library/Philadelphia, PA 01/24/1992
EJBD ARCHIVE EPA 625-3-91-019F Headquarters Library/Washington,DC 01/25/2011
EJBD  EPA 625/3-91/019F Headquarters Library/Washington,DC 06/01/2001
EJED  EPA-625/3-91-019F OCSPP Chemical Library/Washington,DC 05/30/1992
EKAM  EPA/625/3-91/019F Region 4 Library/Atlanta,GA 08/16/1996
EKBD  EPA-625/3-91-019F Research Triangle Park Library/RTP, NC 12/20/2002
EKCD  EPA/625/3-91/019F NHEERL/GED Library/Gulf Breeze,FL 11/20/2018
ELBD  EPA 625-3-91-019F AWBERC Library/Cincinnati,OH 12/20/1996
ELDM  RC91.B33 1991 NHEERL/MED Library/Duluth,MN 08/14/1998
ERAD  EPA 625/3-91-019F Region 9 Library/San Francisco,CA 12/13/1991
ESAD  EPA 625-3-91-019F Region 10 Library/Seattle,WA 05/31/2017
NTIS  PB92-143668 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 01/01/1988
Collation xii, 118 pages
Abstract
The report of a Technical Panel of the U.S. Environmental Protection Agency (EPA) Risk Assessment Forum describes conditions under which the Forum advises EPA risk assessors against using information on certain renal tubule tumors or nephrotoxicity to assess human risk. Risk assessment approaches generally assume that chemicals producing tumors in laboratory animals are a potential cancer hazard to humans. For most chemicals, including many rodent kidney carcinogens, this extrapolation remains appropriate. The scientific studies reviewed by the Technical Panel indicate, however, that some other chemicals induce accumulation of alpha(sub 2u)-globulin, a low-molecular-weight protein, in the male rat kidney. Female rats and other laboratory mammals administered the same chemicals do not accumulate low-molecular-weight protein in the kidney and they do not develop renal tubule tumors. Since humans appear to be more like other laboratory animals than like the male rat, in this special situation, the male rat is not a good model for assessing human risk.
Notes
"Risk Assessment Forum." "EPA/625/3-91/019F." "September 1991." Includes bibliographical references (pages 99-118).