||Diethyldithiocarbamate Increases Distribution of Cadmium to Brain but Prevents Cadmium-Induced Neurotoxicity.
O'Callaghan, J. P. ;
Miller, D. B. ;
||Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC.
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
Dithiocarbamates exhibit potent metal-binding properties which have been exploited in a variety of applications, one of which is chelation therapy for heavy metal toxicity. Such therapy, however, promotes the accumulation of metals in the brain, a side effect which may result in neurotoxicity. To examine this possibility the authors used morphological and biochemical indices to assess the effects of diethyldithiocarbamate (DDC) on cadmium-induced neurotoxicity in the newborn rat. Co-administration of DDC prevented the neurotoxic effects of cadmium while causing a persistent increase in the distribution of cadmium to brain.