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RECORD NUMBER: 268 OF 846

OLS Field Name OLS Field Data
Main Title Development of Locomotor Activity of Rat Pups Exposed to Heavy Metals.
Author Ruppert, P. H. ; Dean, K. F. ; Reiter, L. W. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1985
Report Number EPA/600/J-85/108;
Stock Number PB85-244481
Additional Subjects Toxicology ; Rats ; Laboratory animals ; Reprints ; Heavy metals ; Neurotoxicity ; Locomotor activity ; Cadmium ; Tin/triethyl ; Tin/trimethyl
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB85-244481 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 12p
Abstract
Cadmium (Cd), triethyltin (TET), and trimethyltin (TMT) are heavy metals which are neurotoxic to developing animals. In the present experiment, preweaning assessment of locomotor activity was used to detect and differentiate between the developmental toxicity of these metals. On postnatal day (PND) 5, rat pups received a single injection of either Cd, TET, or TMT. A within-litter design was used for dosing; 1 male and 1 female pup from each litter (N = 10 litters/compound) received either the vehicle, low, medium, or high dosage of the compound. Preweaning motor activity was assessed in 30-min sessions in figure-eight mazes from PND 13 to 21. Motor activity of control animals progressively increased in the initial days of testing, and then both within-session and between-session habituation developed. A single exposure to Cd, TET, and TMT produced hyperactivity by the end of the preweaning period but these metals differed in the day of peak activity, the onset of hyperactivity, and the development of habituation.