Main Title |
Influence of Cadmium, Nickel, and Chromium on Primary Immunity in Mice. |
Author |
Graham, J. A. ;
Miller, F. J. ;
Daniels, M. J. ;
Payne, E. A. ;
Gardner, D. E. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC |
Year Published |
1977 |
Report Number |
EPA/600/J-78/045; |
Stock Number |
PB-287 137 |
Additional Subjects |
Cadmium ;
Metals ;
Immunity ;
Nickel ;
Chromium ;
Toxicology ;
Aerosols ;
Inhalation ;
Physiological effects ;
Mice ;
Laboratory animals ;
Experimental data ;
Concentration(Composition) ;
Responses ;
Dosage ;
Lung ;
Exposure ;
Nickel oxides ;
Reprints ;
Humoral immunity ;
Hemolytic plaque technique ;
Nickel chlorides ;
Chromium chlorides ;
Cadmium chlorides ;
Heavy metals ;
Toxic substances
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB-287 137 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
14p |
Abstract |
The effects of metals on the primary humoral immune system of mice were investigated using a hemolytic plaque technique to determine the number of specific antibody-producing spleen cells. Inhalation of NiCl2 for 2 hr resulted in a significant negative linear dose response, the lowest effective concentration tested being 250 micrograms of Ni/cu m. Following a 2 hr aerosol exposure to NiCl2, the lung cleared Ni on a first-order kinetics basis. A significant reduction in the number of plaques per 10 to the 6th power cells was also observed with exposure to 190 micrograms of Cd/cu m. Analyses of the data from intra-muscularly exposed mice indicated that concentrations greater than or equal to 3.90 micrograms of Ni/g body weight (as NiSO4) and greater than or equal to 9.25 micrograms of Ni/g body weight (as NiCl2) resulted in significant immunosuppression. Intramuscular treatments with NiO, CdCl2, and CrCl3 had no effect at the concentrations tested. |