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RECORD NUMBER: 8 OF 8

OLS Field Name OLS Field Data
Main Title Toxicological Review of Carbon Tetrachloride (CAS No. 56-23-5) in Support of Summary Information on the Integrated Risk Information System (IRIS).
CORP Author Environmental Protection Agency, Washington, DC. National Center for Environmental Assessment.
Year Published 2010
Report Number EPA/635/R-08/005F
Stock Number PB2010-113839
Additional Subjects Toxicity ; Carbon tetrachloride ; Health effects ; Risk assessment ; Environmental exposure ; Health hazards ; Carcinogens ; Chemical properties ; Humans ; Inhalation ; Respiratory system ; Integrated Risk Information System (IRIS) ; CAS No 56-23-5
Holdings
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NTIS  PB2010-113839 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 01/21/2011
Collation 473p
Abstract
This document presents background information and justification for the Integrated Risk Information System (IRIS) Summary of the hazard and dose-response assessment of carbon tetrachloride. IRIS Summaries may include oral reference dose (RfD) and inhalation reference concentration (RfC) values for chronic and other exposure durations, and a carcinogenicity assessment. The RfD and RfC, if derived, provide quantitative information for use in risk assessments for health effects known or assumed to be produced through a nonlinear (presumed threshold) mode of action. The RfD (expressed in units of mg/kg-day) is defined as an estimate (with uncertainty spanning perhaps an order of magnitude) of a daily exposure to the human population (including sensitive subgroups) that is likely to be without an appreciable risk of deleterious effects during a lifetime. The inhalation RfC (expressed in units of mg/m3) is analogous to the oral RfD, but provides a continuous inhalation exposure estimate. The inhalation RfC considers toxic effects for both the respiratory system (portal of entry) and for effects peripheral to the respiratory system (extrarespiratory or systemic effects).