Record Display for the EPA National Library Catalog
RECORD NUMBER: 2 OF 2
|OLS Field Name||OLS Field Data|
|Main Title||Initial Submission: Letter from Rohm and Haas Company to USEPA re: Neurotoxicity in Female Rats with Ethyl 4,4,4-trifluoroaceto-acetate, in Preliminary Results of Acute Study, with Cover Letter dated 10/05/99.|
|CORP Author||Rohm and Haas Co., Philadelphia, PA.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.|
|Publisher||7 Oct 1999|
|Additional Subjects||Toxicity ; Neurotoxicity ; Females ; Rats ; Corn oil ; Gavage ; Dosage ; Laboratory animals ; Ethyl 4,4,44rifluoroacetoacetate ; Acute toxicity tests ; CAS No. 372-31-6|
This letter transmits preliminary results of an acute toxicity test indicating neurotoxic effects to female rats for ethyl 4,4,44rifluoroacetoacetate (CAS No. 372-31-6). Ethyl 4,4,4-trifluoroacetoacetate (ETFAA) was suspended in corn oil and administered by oral gavage to seven groups of six female rats/group at dose levels of 0, 25, 100, 17.5, 250, 500, or 750 mg/kg of body weight at a constant volume of 5 ml/kg. Clinical signs indicative of neurotoxicity (i.e., ataxia, tremors, fasciculations, prostration, salivation) were observed at 250 mg/kg and above after multiple doses.