Record Display for the EPA National Library Catalog

RECORD NUMBER: 7 OF 20

OLS Field Name OLS Field Data
Main Title In vitro Studies to Evaluate Glycol Ethers as Substrates for Alcohol Dehydrogenase (Sanitized).
CORP Author Dow Chemical Co., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 2000
Report Number 86-890001231S
Stock Number OTS0520741
Additional Subjects Toxicology ; Health effects ; 1-methoxy-2-propanol (107-98-2) ; Pharmaco Kinetics ; Mammals ; Other Mammals ; In Vitro ; Toxic substances ; Laboratory animals ; CAS No 107-98-2 ; CAS No 109-86-4 ; CAS No 110-80-5 ; CAS No 111-76-2 ; CAS No 111-77-3 ; CAS No 111-90-0 ; CAS No 112-34-5 ; CAS No 34590-94-8
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NTIS  OTS0520741 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/10/2010
Collation 13p
Abstract
Metabolism of Dowanol EB (ethylene glycol mono-n-butyl ether) was evaluated in vitro with an equine liver alcohol dehydrogenase assay obtained from the Sigma Chemical Company. The Vmax, Km, and Vmax/Km were 4.06, 1.18X10E-3, and 3.50, respectively. The authors concluded that alcohol dehydrogenase has a high affinity for the test compound, indicating that the test compound is probably metabolized to a significant extent by this enzyme in vivo.