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RECORD NUMBER: 5 OF 11

OLS Field Name OLS Field Data
Main Title In Vitro Microbial Mutagenicity Studies of Isocyanic Acid, Methylene Di-para-phenylene Ester with Cover Letter dated 04/30/1984.
CORP Author Du Pont de Nemours (E.I.) and Co., Wilmington, DE. Haskell Lab. for Toxicology and Industrial Medicine.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1984
Report Number FYI-AX-0584-0303
Stock Number OTS0000303-0
Additional Subjects Toxicity ; Health effects ; Genotoxicity ; Gene mutations ; Bacteria ; In vitro ; CAS No 101-68-8
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NTIS  OTS0000303-0 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 04/28/2010
Collation 63p
Abstract
Methylenedi-para-phenylene ester of isocyanic acid was examined in Salmonella typhimurium tester strains TA1535, TA1537, TA1538, TA98 and TA100 with and without rat liver homogenate S9 fraction to provide metabolic activation. Using the plate incorporation technique at doses of 0.5, 1.0, 1.5, 2.0 and 2.5 mg/plate, the test article was found to be mutagenic to strains TA98 and TA100 in the presence of activation; the greatest effect (0.27 revertants/uMol) was observed in TA100. In the absence of activation, a mutagenic effect was not observed in any strains. The investigators reported that preliminary cytotoxicity screening had been performed.