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OLS Field Name OLS Field Data
Main Title Evaluation of the potential carcinogenicity of o-toluidine (95-53-4) /
CORP Author Environmental Monitoring and Services, Inc., Washington, DC. ;Syracuse Research Corp., NY.;Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.
Publisher U.S. Environmental Protection Agency, Office of Emergency and Remedial Response ;
Year Published 1988
Report Number EPA/600/8-91/187; EPA-68-03-3112; EPA-68-03-3182; OHEA-C-073-182
Stock Number PB93-201200
Subjects O-Toluidine--Carcinogenicity.
Additional Subjects Toluidines ; Toxicity ; Risk assessment ; Public health ; Exposure ; Hazardous materials ; Neoplasms ; Tolerances(Physiology) ; Carcinogenicity ; Dose-response relationships ; CAS 95-53-4
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB93-201200 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 01/01/1988
Collation 22 pages ; 28 cm
Abstract
The assessment of o-toluidine for potential carcinogenicity is based on data from studies using o-toluidine hydrochloride, since o-toluidine is rapidly and completely converted to the hydrochloride after oral ingestion. Therefore, this profile summarizes the relevant cancer literature on o-toluidine hydrochloride. o-Toluidine is a potential human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment. Evidence on potential carcinogenicity from animal studies is 'Sufficient', and the evidence from human studies is 'Inadequate'. The potentcy factor (F) for o-toluidine is estimated to be 0.069 (mg/kg/day)-1, placing it in potency group 3 according to the CAG's methodology for evaluating potential carcinogens. Combining the weight-of-evidence group and the potency group, o-toluidine is assigned a 'LOW' hazard ranking.
Notes
Cover title. "June 1988." Includes bibliographical references. Microfiche.