Record Display for the EPA National Library Catalog
RECORD NUMBER: 1 OF 3
|OLS Field Name||OLS Field Data|
|Main Title||Evaluation of the potential carcinogenicity of o-toluidine (95-53-4) /|
|CORP Author||Environmental Monitoring and Services, Inc., Washington, DC. ;Syracuse Research Corp., NY.;Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.|
|Publisher||U.S. Environmental Protection Agency, Office of Emergency and Remedial Response ;|
|Report Number||EPA/600/8-91/187; EPA-68-03-3112; EPA-68-03-3182; OHEA-C-073-182|
|Additional Subjects||Toluidines ; Toxicity ; Risk assessment ; Public health ; Exposure ; Hazardous materials ; Neoplasms ; Tolerances(Physiology) ; Carcinogenicity ; Dose-response relationships ; CAS 95-53-4|
|Collation||22 pages ; 28 cm|
The assessment of o-toluidine for potential carcinogenicity is based on data from studies using o-toluidine hydrochloride, since o-toluidine is rapidly and completely converted to the hydrochloride after oral ingestion. Therefore, this profile summarizes the relevant cancer literature on o-toluidine hydrochloride. o-Toluidine is a potential human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment. Evidence on potential carcinogenicity from animal studies is 'Sufficient', and the evidence from human studies is 'Inadequate'. The potentcy factor (F) for o-toluidine is estimated to be 0.069 (mg/kg/day)-1, placing it in potency group 3 according to the CAG's methodology for evaluating potential carcinogens. Combining the weight-of-evidence group and the potency group, o-toluidine is assigned a 'LOW' hazard ranking.
Cover title. "June 1988." Includes bibliographical references. Microfiche.