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RECORD NUMBER: 2 OF 4

Main Title Initial Submission: Letter from E. I. Dupont de Nemours and Company to USEPA Reporting Results of Acute Inhalation Study in Rats of 1-Butene, 4-Bromo-3,3,4,4-Tetrafluoro, dated 01/29/2001.
CORP Author Du Pont de Nemours (E.I.) and Co., Newark, DE. Haskell Lab. for Toxicology and Industrial Medicine.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 2001
Report Number 8EHQ-0101-14857
Stock Number OTS0560001
Additional Subjects Toxicology ; Health effects ; Toxic substances ; 1-butene ; Acute toxicity ; Mammals ; Rats ; Inhalation ; CAS No 18599-22-9
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  OTS0560001 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 5p
Abstract
This letter is to inform you of the results of a pre-1977 (1975) acute inhalation study that recently came to our attention, on the above referenced test substance. The test substance was administered by inhalation (whole body exposure) to groups of 6 male Ch-R CD rats per concentration for approximately 4 hours, followed by a 14-day observation period. The exposure concentrations were 628, 1841, 7116, or 19,300 ppm (nominal). Rats were monitored for body weight changes and clinical signs of toxicity. No animals died and there were no reductions in body weight gain. Rats exposed to all concentrations showed signs of lethargy. Rats exposed to 19,300 ppm also demonstrated temporary prostration and a loss of righting when attempting to walk. These clinical signs were observed during exposure and rats appeared normal when removed from the exposure chamber. Under these experimental conditions, the clinical signs described above are being reported in accordance with the guidance given in the EPA TSCA Section 8(e) Reporting Guide (June 1991).