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RECORD NUMBER: 3 OF 6

OLS Field Name OLS Field Data
Main Title Electrophysiological Measures of Visual and Auditory Function as Indices of Neurotoxicity (Journal Version).
Author Otto, D. ; Hudnell, K. ; Boyes, W. ; Janssen, R. ; Dyer, R. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher 1988
Year Published 1988
Report Number EPA/600/D-88/079;
Stock Number PB89-110415
Additional Subjects Electrophysiology ; Visual evoked potentials ; Auditory evoked potentials ; Toxicity ; Nervous system ; Humans ; Laboratory animals ; Brain stem ; Reprints ;
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB89-110415 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/14/1989
Collation 14p
Abstract
The application of auditory and visual evoked potential (VEP) to neurotoxicity testing of humans and animals is reviewed. VEPs elicited by flash, reversing-checkerboard patterns, and sine wave grating are described. The flash evoked potential in rats is altered by exposure to many heavy metals, pesticides and solvents. The brainstem auditory evoked potential also appears to be sensitive to neurotoxic chemicals, but the evidence available is limited. The homology of auditory and visual evoked potentials in rats and humans is useful for cross-species extrapolation in neurotoxicology research.