Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Corticosterone Hypersecretion in Preweanling Rats Exposed Neonatally to Trimethyltin.
Author Stanton, M. E. ; Coussons, M. E. ; Kuhn, C. M. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1992
Year Published 1992
Report Number EPA/600/J-92/311;
Stock Number PB92-227529
Additional Subjects Toxicity ; Trimethyltin ; Teratogenic compounds ; Corticosterone ; Rats ; Stress(Physiology) ; Organ weight ; Body weight ; Exposure ; Reprints ; Hypersecretion
Library Call Number Additional Info Location Last
NTIS  PB92-227529 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/01/1993
Collation 10p
Developmental neuro-toxicity may be influenced by effects of a compound on endocrine function. Here the authors report that developmental exposure to TMT increases the corticosterone (CS) response to stress in developing rat pups. Long-Evans rat pups were injected i.p. with either 6 mg/kg TMT hydroxide (in 10 microliter/g BW NaCl) or vehicle on Postnatal Day 5 (PND5) or 10 and were then tested for their CS response to restraint stress on PND12, 16, or 20. TMT exposure on PND5 (Experiment 1) resulted in CS hypersecretion relative to vehicle-injected controls on PND12 and 16 but not PND20. TMT exposure on PND10 (Experiment 2) had no effect at PND12 but elevated CS over vehicle controls at PND16 and 20. PND15 exposure to TMT resulted in CS hypersecretion in pups tested on PND20. Neonatal organotin exposure appears to alter CS secretion in a manner that is influenced by age of exposure and age of testing.