||Corticosterone Hypersecretion in Preweanling Rats Exposed Neonatally to Trimethyltin.
Stanton, M. E. ;
Coussons, M. E. ;
Kuhn, C. M. ;
||Health Effects Research Lab., Research Triangle Park, NC.
Teratogenic compounds ;
Organ weight ;
Body weight ;
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Developmental neuro-toxicity may be influenced by effects of a compound on endocrine function. Here the authors report that developmental exposure to TMT increases the corticosterone (CS) response to stress in developing rat pups. Long-Evans rat pups were injected i.p. with either 6 mg/kg TMT hydroxide (in 10 microliter/g BW NaCl) or vehicle on Postnatal Day 5 (PND5) or 10 and were then tested for their CS response to restraint stress on PND12, 16, or 20. TMT exposure on PND5 (Experiment 1) resulted in CS hypersecretion relative to vehicle-injected controls on PND12 and 16 but not PND20. TMT exposure on PND10 (Experiment 2) had no effect at PND12 but elevated CS over vehicle controls at PND16 and 20. PND15 exposure to TMT resulted in CS hypersecretion in pups tested on PND20. Neonatal organotin exposure appears to alter CS secretion in a manner that is influenced by age of exposure and age of testing.