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RECORD NUMBER: 2 OF 244

OLS Field Name OLS Field Data
Main Title 5-Methylhexanoic Acid Developmental Toxicity Testing.
Author Narotsky., M. G. ;
CORP Author ManTech Environmental Technology, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher Jan 91
Year Published 1991
Report Number EPA-68-02-4450; EPA/600/1-91/001;
Stock Number PB91-141838
Additional Subjects Toxicity ; Aliphatic acids ; Valproate ; Teratogens ; Rats ; Dose-response relationships ; Females ; Body weight ; Tables(Data) ; Reproduction(Biology) ; Litter size ; Structure-activity relationship ; Parturition ; 5-Methylhexanoic acid
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB91-141838 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/13/1991
Collation 23p
Abstract
As part of an investigation of the developmental effects and structure-activity relationships of aliphatic acids, 5-methylhexanoic acid was administered by gavage to Sprague-Dawley rats on gestation days 6-15 at doses of 0, 300, and 400 mg/kg/day. The dams were allowed to deliver and their litters were examined through postnatal day 6. Pups that were found dead were examined for soft-tissue alterations. On day 6, two survivors per litter were preserved for skeletal examination. Maternal toxicity was demonstrated at both 300 and 400 mg/kg by reduced weight gains, altered respiration (rales, dyspnea) and death. Body weight losses early in the treatment period were also evident at 400 mg/kg. In spite of the marked maternal toxicity present, there were no clear developmental effects; litter size, pre- and postnatal viability, and pup weights were unaffected by treatment. Skeletal examinations of selected pups also revealed no compound effects.