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RECORD NUMBER: 5 OF 30

OLS Field Name OLS Field Data
Main Title Comparative Effects of Hypoxia on Behavioral Thermoregulation in the Rats, Hamsters, and Mice.
Author Gordon, C. J. ; Fogelson, L. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher 1991
Year Published 1991
Report Number EPA/600/J-91/020;
Stock Number PB91-183467
Additional Subjects Hypoxia ; Animal behavior ; Body temperature regulation ; Rats ; Mice ; Hamsters ; Statistical analysis ; Species diversity ; Comparative evaluations ; Oxygen ; Reprints ;
Holdings
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Status
NTIS  PB91-183467 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 09/04/1991
Collation 8p
Abstract
Recent studies using reptiles and other ectothermic species have shown that hypoxia lowers the set-point for the control of body temperature. This is characterized by a preference for cooler ambient (T(sub a)) and deep body temperatures (T(sub b)) when placed in a temperature gradient. To elucidate the presence of this effect in mammals, the selected T(sub a) and T(sub b) of three rodent species, mouse, hamster, and rat, were measured while subjected to graded hypoxia in a temperature gradient. Individual animals were placed in the gradient for 30 min. Percentage O2 of air entering the gradient was then reduced to a constant level for a period of 60 min by dilution with nitrogen. T(sub b) was significantly reduced in all species at O2 levels of 5.5 to 10%. Selected T(sub a) was significantly reduced in the mouse at O2 levels of 5.5 and 7.3%. Selected T(sub a) of the hamster and rat were reduced slightly at percentage O2 levels of 5.8 and 7.4%, respectively; however, the effect was not statistically significant. Both species exhibited a significant reduction in selected T(sub a) during hypoxia concomitant with hypothermia. These data support the hypothesis that hypoxia lowers the set-point for the control of body temperature in rodents.