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RECORD NUMBER: 21 OF 30

OLS Field Name OLS Field Data
Main Title Relationship between Cholinesterase Inhibition and Thermoregulation Following Exposure to Diisopropyl Fluorophosphate in the Rat.
Author Gordon, C. J. ; Fogelson, L. ; Richards, J. ; Highfill., J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;NSI Technology Services Corp., Research Triangle Park, NC.
Publisher c1991
Year Published 1991
Report Number EPA/600/J-92/109;
Stock Number PB92-158658
Additional Subjects Diisopropylfluorophosphate ; Body temperature regulation ; Cholinesterase inhibitors ; Toxicology ; Rats ; Exposure ; Dose-response relationships ; Acetylcholinesterase ; Blood ; Reprints ;
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB92-158658 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 08/28/1992
Collation 10p
Abstract
The study examined the relationship between inhibition of cholinesterase activity (CA) and thermoregulatory response in the rat following exposure to the organophosphate (OP), diisopropyl fluorophosphate (DFP). Male Long-Evans rats were injected with DFP dissolved in peanut oil in doses ranging from 0 to 1.5 mg/kg (s.c.). Colonic T(sub col) and tail skin temperature T(sub tail) were recorded at 0, 1, 2, and 3 hr post-injection. At 3 hr post-injection the rat was sacrificed and a blood sample was taken by cardiac puncture and analyzed for CA. There was a biphasic dose effect of DFP on T(sub col) with slight but significant elevation in T(sub col) in the dose range of 0.01 to 0.5 mg/kg and a significant depression in T(sub col) at doses of 1.0 and 1.5 mg/kg. There was a dose-dependent fall in CA with DFP administration in the erythrocyte, plasma, and whole blood fractions. Hypothermia was associated with 80 to 87% inhibition in CA, whereas the elevation in T(sub col) was associated with 20 to 70% inhibition in CA. DFP also elicited significant elevations in T(sub tail) (Copyright (c) 1991 Elsevier Science Publishers.)