Record Display for the EPA National Library Catalog
RECORD NUMBER: 17 OF 20
|OLS Field Name||OLS Field Data|
|Main Title||Relationship Between Depression of Brain or Plasma Cholinesterase and Paralysis in Chickens Caused by Certain Organic Phosphorus Compounds.|
|CORP Author||Communicable Disease Center, Atlanta, Ga.|
|Stock Number||PB-280 567; PB-280 565|
|Additional Subjects||Phosphorus organic compounds ; Toxicology ; Relationship ; Brain ; Cholinesterase inhibitors ; Blood plasma ; Paralysis ; Chickens ; Laboratory animals ; Experimental data ; Reprints ; Toxic substances|
A study has been made of the relationship between the inhibition of plasma or brain cholinesterase of the chicken and the paralytic syndromes caused by DFP, TOCP, malathion, ronnel, EPN, and Trithion. DDVP and Dipterex served as nonparalytic controls. TOCP was the only compound tested that was a specific inhibitor of brain cholinesterase. All compounds except EPN inhibited plasma cholinesterase. All compounds tested inhibited brain true and/or pseudocholinesterase. All paralytic compunds tested except DFP produced a prologed inhibition of brain true and/or pseudocholinesterase which lasted for 5 to 17 days. It was concluded that no causative relationship exists between the prolonged inhibition of brain cholinesterase and the paralytic syndromes. The regeneration of brain cholinesterase after inhibition with DFP, Dipterex, or DDVP is probably due to protein synthesis de novo; the prologed inhibition of these enzymes after the administation of the other compounds may be due in part to the persistence of the inhibitor in the body.
Included in PB-280 565, Journal articles on toxicology. Group 12.