||Multicompartment Kinetic Models for Lead. 1. Bone Diffusion Models for Long-Term Retention.
Marcus, A. H. ;
||Washington State Univ., Pullman. Dept. of Pure and Applied Mathematics.;Health Effects Research Lab., Research Triangle Park, NC.
Blood plasma ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
The long-term retention of lead in bone poses a number of difficulties for the usual multicompartment models. The use of diffusion models based on exchange of lead between blood in canaliculi and the crystalline bone of the osteon allows a linear compartmental approximation suitable for statistical estimation of kinetic parameters in peripheral compartments. The model is applied to lead retention by beagle dogs.