Record Display for the EPA National Library Catalog
RECORD NUMBER: 12 OF 20
|OLS Field Name||OLS Field Data|
|Main Title||Multicompartment Kinetic Model for Lead. Part 3. Lead in Blood Plasma and Erythrocytes.|
|Author||Marcus, A. H. ;|
|CORP Author||Washington State Univ., Pullman. Dept. of Pure and Applied Mathematics.;Health Effects Research Lab., Research Triangle Park, NC.|
|Additional Subjects||Lead(Metal) ; Blood plasma ; Mathematical models ; Concentration(Composition) ; Erythrocytes ; Reprints ; Kinetic models|
Multicompartment models have been fitted to experimental data on plasma lead and blood lead concentrations of subjects studied by de Silva (1981, Brit. J. Industr. Med. 38, 209-217) and one subject studied by Manton and Malloy (1983, Brit. J. Industr. Med., 40, 51-57). Nonlinear models for plasma lead vs. blood lead in populations provide significantly better descriptions than does a linear model. Short-term kinetic data do not clearly resolve the precise nonlinear mechanism, however. Parameters of plasma and erythrocyte distribution in a single subject were significantly different on two occasions.