||Long-Term Variation Study of Blood Plasma Levels of Chloroform and Related Purgeable Compounds.
Pfaffenberger, Carl D. ;
Peoples, Anita J. ;
||Miami Univ., FL. School of Medicine.;Health Effects Research Lab., Research Triangle Park, NC.
Blood plasma ;
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Values for circulating plasma chloroform or chloroform precursors of 25 white adult females were monitored for 6 months during Phase I of a four-phase long term variation study. The data suggested four major exposure categories. Category I (20%) had average chloroform levels < 10 ppb* and variation ranges < 10 ppb* and variation ranges < 10 ppb. Category II (24%) had average levels of 10-25 ppb and ranges of < 10 ppb. Category III (20%) had average levels of 10-25 ppb and ranges of < 20 ppb. Category IV (28%) had average chloroform levels of > 25 ppb and variation ranges > 20 ppb. Although the participants had been carefully screened to exclude incidents of occupational and recreational exposure, three subjects in category IV experienced obvious incidence of acute exposure to either chloroform or a chloroform precursor. In these situation circulating plasma chloroform levels were between 1655 ppb and 4000 ppb.