Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Toluene Levels in Blood and Brain of Rats during and after Respiratory Exposure.
Author Benignus, Vernon A. ; Muller, Keith E. ; Barton, Curtis N. ; Brittikofer, John A. ;
CORP Author North Carolina Univ. at Chapel Hill.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1981
Report Number EPA-600/J-81-180;
Stock Number PB83-189670
Additional Subjects Toluene ; Bioassay ; Rats ; Laboratory animals ; Blood analysis ; Brain ; Reprints ; Air pollution effects(Animals)
Library Call Number Additional Info Location Last
NTIS  PB83-189670 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 10p
Eighty rats were exposed to 575 ppm toluene by inhalation for up to 240 min. Animals in one group were sacrificed during exposure at 15, 30, 60, 120, or 240 min. Following a 240-min exposure, groups of rats were sacrificed at 15, 30, 120, or 240 min. Blood was drawn from the vena cava of sacrified subjects. Brains were extracted and homogenized. Blood and brain tissue were assayed for toluene by gas chromatography. One-compartment pharmacokinetic models were fitted to predict toluene levels in blood and whole brain as a function of time.