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RECORD NUMBER: 46 OF 66

OLS Field Name OLS Field Data
Main Title Mutagenicity of Benzo(a)Pyrene Metabolites Generated on the Isolated Perfused Lung Following Particulate Exposure (Journal Version).
Author Schoeny, Rita ; Warshawsky, David ;
CORP Author Cincinnati Univ., OH. Coll. of Medicine.;Health Effects Research Lab., Research Triangel Park, NC.
Year Published 1983
Report Number EPA-68-02-2975; EPA-600/J-83-030;
Stock Number PB83-244087
Additional Subjects Mutagens ; Public health ; Air pollution ; Particles ; Laboratory animals ; Rabbits ; Exposure ; Respiratory system ; Metabolism ; Isotopic labeling ; Chemical analysis ; Blood analysis ; Reprints ; Benzo(a)pyrene
Holdings
Library Call Number Additional Info Location Last
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Status
NTIS  PB83-244087 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 15p
Abstract
The isolated perfused rabbit lung (IPL) is being used to study the effects of particulate exposure on the pulmonary metabolism of benzo(a)pyrene (BaP). Pasturealla-free New Zealand white rabbits were treated intraperitoneally with BaP prior to kill. The isolated lungs were then administered either (14)C-labeled BaP alone or BaP plus Fe2O3 or fly ash by intratracheal injection. Rates of appearance of BaP metabolites in the perfusing blood were determined. The extent of metabolism, distribution of metabolites, and types of metabolites produced were quantified for various lung tissue types by high-performance liquid chromatography and liquid scintillation spectrometry.