||Role of Inhaled Particles in the Pathophysiology of Cardiovascular Disease.
||California Univ., Irvine.; California State Air Resources Board, Sacramento. Research Div.; California Environmental Protection Agency, Sacramento.
Cardiovascular disease ;
Respiratory systems ;
Air pollution effects(Animals) ;
Environmental exposure ;
Laboratory animals ;
Heart disease ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
The mechanisms by which particulate matter (PM) exposure disrupts cardiac function and worsens cardiovascular disease (CVD) are not well understood. There is a growing body of knowledge that suggests that PM exposure can induce inflammatory changes in blood vessels and exacerbate atherogenesis leading to the development of atherosclerotic plagues and lesions. We hypothesized that PM exposure would abnormally activate endothelial cells and induce vascular inflammation that will lead to the accelerated formation of arterial plagues which are a hallmark of atherosclerosis.