Record Display for the EPA National Library Catalog

RECORD NUMBER: 35 OF 37

OLS Field Name OLS Field Data
Main Title Role of Inhaled Particles in the Pathophysiology of Cardiovascular Disease.
Author M. Kleinman
CORP Author California Univ., Irvine.; California State Air Resources Board, Sacramento. Research Div.; California Environmental Protection Agency, Sacramento.
Year Published 2010
Report Number CARBRA-04-320; ARB/R10-904
Stock Number PB2011-100258
Additional Subjects Inhalation ; Particulates ; Pothophysiology ; Cardiovascular disease ; Respiratory systems ; Air pollution effects(Animals) ; Environmental exposure ; Atherosclerosis ; Biomarkers ; Mice ; Laboratory animals ; Heart disease ; California
Holdings
Library Call Number Additional Info Location Last
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Status
NTIS  PB2011-100258 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 07/20/2011
Collation 56p
Abstract
The mechanisms by which particulate matter (PM) exposure disrupts cardiac function and worsens cardiovascular disease (CVD) are not well understood. There is a growing body of knowledge that suggests that PM exposure can induce inflammatory changes in blood vessels and exacerbate atherogenesis leading to the development of atherosclerotic plagues and lesions. We hypothesized that PM exposure would abnormally activate endothelial cells and induce vascular inflammation that will lead to the accelerated formation of arterial plagues which are a hallmark of atherosclerosis.