Overview and future of molecular biomarkers of exposure and early disease in environmental health / William A. Suk and Samuel H. Wilson -- Ethical and legal considerations in biological markers research / Richard R. Sharp and Paul H. Zigas -- Scientific and policy issues affecting the future of environmental health services / Bernard D. Goldstein -- Ecogenetics : genetic susceptibility to environmental adversity / Daniel W. Nebert -- Toxicogenomics and pharmacogenomics : basic principles, potential applications, and issues / F. Peter Guengerich -- Individual susceptibility to exposures : a role for genetic variation in DNA repair genes / Harvey W. Mohrenweiser -- Studies of DNA repair and human cancer : an update / Marianne Berwick, Giuseppe Matullo, and Paolo Vineis -- DNA adducts as biomarkers of DNA damage in lung cancer / Suryanarayana V. Vulimiri and John DiGiovanni -- Tamoxifen-DNA adducts : biomarkers for drug-induced endometrial cancer / Shinya Shibutani, Naomi Suzuki, and Arthur P. Grollman -- Polycyclic aromatic hydrocarbon DNA adducts and human cancer / Mikhail F. Denissenko, Moon-shong Tang, and Gerd P. Pfeifer -- Quantitative PCR : a sensitive biomarker of gene-specific DNA damage and repair / Bennett Van Houten, Yiming Chen, Janine H. Santos, and Bhaskar S. Mandavilli -- Fidelity of DNA synthesis as a molecular biomarker / Kandace Williams -- Mutational specificity of environmental carcinogens / Kathleen Dixon and Mario Medvedovic. Learning-induced modulation of neural cell adhesion molecule polysialylation state as a biomarker of prior inorganic lead exposure during the early postnatal period / Keith J. Murphy, Helen C. Gallagher, and Ciaran M. Regan -- Molecular biomarkers for mercury / Thomas W. Clarkson and Nazzareno Ballatori -- Validity of mercury exposure biomarkers / Philippe Grandjean, Poul J. J²rgensen, and Pál Weihe -- Urinary arsenic species in relation to drinking water, toenail arsenic concentrations and genetic polymorphisms in GSTM1 in New Hampshire / Margaret R. Karagas, Heather H. Nelson, Karl T. Kelsey, Steven Morris, Joel D. Blum, Tor D. Tosteson, Mark Carey, Xiufen Lu, and X. Chris Le -- Molecular responses of mammalian cells to nickel and chromate exposure / Max Costa, Konstantin Salnikow, Jessica E. Sutherland, Thomas Kluz, Wu Peng, and Moon-shong Tang -- Chromium : exposure, toxicity, and biomonitoring approaches / Anatoly Zhitkovich -- Using plankton food web variables as indicators for the accumulation of toxic metals in fish / Carol L. Folt, Celia Y. Chen, and Paul C. Pickhardt. Validation of exposure and risk biomarkers : aflatoxin as a case study / John D. Groopman, Peta E. Jackson, Paul Turner, Christopher P. Wild, and Thomas W. Kensler -- Biomarkers of early effect in the study of cancer risk / Laura Gunn, Lupoing Zhang, Matthew S. Forrest, Nina T. Holland, and Martyn T. Smith -- Proteomics in toxicology : an experience with gentamicin / Sandy Kennedy, M.D. Kelly, C. Moyses, R. Ames, and R. Parekh -- Xenopus Iaevis genomic biomarkers for environmental toxicology studies / Perry J. Blackshear -- Molecular biomarkers targeting signal transduction systems : the AH receptor pathway / Timothy R. Fennell, Frederick J. Miller, and William F. Greenlee -- Measuring oxidative damage caused by environmental stressors : potential for reversal and abatement / Robert A. Floyd -- Biomarkers of male reproductive health / Anne L. Golden -- Peripheral benzodiazepine receptors : molecular biomarkers of neurotoxicity / Tomás R. Guilarte -- Biomarkers of organ injury from chemical exposure : concurrent inflammation as a determinant of susceptibility / Robert A. Roth and Patricia E. Ganey -- Modulation of GAP junctional communication by "epigenetic" toxicants : a shared mechanism in teratogenesis, carcinogenesis, atherogenesis, immunomodulation, reproductive and neurotoxicities / James E. Trosko, Chia-Cheng Chang, and Brad Upham -- Exposure to POPs and other congeners / Stephen H. Safe -- Polybrominated diphenyl ethers : route, dose, and kinetics of exposure to humans / ïAke Bergman, Lars Hagmar, Peter Hèoglund, and Andreas Sjèodin -- Bioanalytical approaches for the detection of dioxin and related halogenated aromatic hydrocarbons / Michael S. Denson, Scott R. Nagy, Michael Ziccardi, George C. Clark, Michael Chu, David J. Brown, Guomin Shan, Yukio Sugawara, Shirley J. Gee, James Sanborn, and Bruce D. Hammock -- Application of biomarkers to population studies on food chain contaminants in Nunavik (Arctic Quebec, Canada) / âEric Dewailly, Pierre Ayotte, Marc Rhainds, Suzanne Bruneau, Chris Furgal, Jacques Grondin, Benoãit Lévesque, Carole Blanchet, Daria Pereg, and Gina Muckle -- University-Community Partnership for the Study of Environmental Contamination at Akwesasne / David O. Carpenter, Alice Tarbell, Edward Fitzgerald, Michael J. Kadlec, David O'Hehir, and Brian Bush -- Electronic biosensing / G.R. Facer, O.A. Saleh, D.A. Notterman, and L.L. Sohn -- Two-photon fluorescence microscopy : a review of recent advances in deep-tissue imaging / Chen-Yuan Dong, Lily Hsu, Ki-Hean Kim, Christof Buehler, Peter D. Kaplan, Thomas D. Hancewicz, and Peter T.C. So. This book provides coverage of the current status and future prospects of a field that will play a key role in emerging areas of public health and medicine. It focuses on the risk to human and environmental health from exposure to persistent organic pollutants, heavy metals, airborne toxics, environmental estrogens, and other environmental pollutants. This material will aid researchers in understanding, treating, and preventing environmentally induced disease.