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RECORD NUMBER: 42 OF 60

OLS Field Name OLS Field Data
Main Title Physiologically-Based Pharmacokinetic Modeling.
Author Andersen, M. E. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Pharmacokinetics Branch.
Publisher cJan 94
Year Published 1994
Report Number EPA/600/J-94/319;
Stock Number PB94-197175
Additional Subjects Pharmacokinetics ; Physiology ; Biological models ; Aromatic hydrocarbons ; Chlorohydrocarbons ; Metabolism ; Dose-response relationships ; Species diversity ; Risk assessment ; Retinoids ; Volatile organic compounds ; Reprints ; Physiologically-based pharmacokinetic models
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB94-197175 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 11/11/1994
Collation 10p
Abstract
Physiologically-based pharmacokinetic (PB-PK) models attempt to provide both a realistic anatomic description of the animal to which a drug or toxic chemical has been administered and a biologically accurate representation of the physiological pathways for chemical storage, metabolism, and elimination in the animal. Because these models explicitly incorporate information about the biological factors which affect chemical disposition, they are particularly useful for high- to low-dose and interspecies extrapolation of pharmacokinetics. The complexity of any particular PB-PK model depends on the chemical studied and the objectives underlying model development. The primary focus of the brief overview is the structure of PB-PK models developed for three specific classes of chemicals: volatile organic compounds (VOCs), dioxin-like chlorinated aromatic hydrocarbons, and retinoids. In addition, the risk assessment objectives underpinning model development and the continuing data needs in refining and extending these models are briefly discussed. (Copyright (c) 1994 Drug Information Association Inc.)