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RECORD NUMBER: 21 OF 22

OLS Field Name OLS Field Data
Main Title Toxicokinetics and Metabolism of Aniline and 4-Chloroaniline in Medaka ('Oryzias latipes').
Author Bradbury, S. P. ; Dady, J. M. ; Fitzsimmons, P. N. ; Voit, M. M. ; Hammermeister., D. E. ;
CORP Author Environmental Research Lab.-Duluth, MN. ;Wisconsin Univ.-Superior. Lake Superior Research Inst. ;AScI Corp., Duluth, MN.
Publisher c1993
Year Published 1993
Report Number EPA/600/J-94/188;
Stock Number PB94-163672
Additional Subjects Anilines ; Metabolism ; Fishes ; Toxicity ; Models ; In vitro analysis ; In vivo analysis ; Water pollution effects(Animals) ; Biotransformation ; Liver microsomes ; Dose-response relationships ; Environmental monitoring ; Chronic exposure ; Primary amines ; Nitrogen ; Acetylation ; Enzymes ; Hydroxylation ; Oxidation ; Reprint ; 4-Chloroaniline ; Medaka ; Oryzias latipes ; BCF(Bioconcentration factor) ; 2-Compartment model ; Toxicokinetics
Holdings
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Status
NTIS  PB94-163672 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 09/01/1994
Collation 12p
Abstract
The in vivo toxicokinetics and in vitro hepatic microsomal metabolism of ((14)C)4-chloroaniline in medaka (Oryzias latipes) were investigated to provide a basis upon which to interpret the toxicological responses of small aquarium fish to aniline derivatives. During static aqueous exposures of up to 320 min, parent equivalents failed to reach steady state and results from depuration studies clearly demonstrated biphasic elimination. The toxicokinetics and in vivo metabolism of both aniline and 4-chloroaniline were best described by a two-compartment model that was consistent with the assumption that metabolites of the parent amines were accumulating in the fish. (Copyright (c) 1993 Academic Press, Inc.)