Record Display for the EPA National Library Catalog
RECORD NUMBER: 360 OF 1241
|OLS Field Name||OLS Field Data|
|Main Title||Cytotoxicity of Halogenated Alkanes in Primary Cultures of Rat Hepatocytes from Normal, Partial Hepatectomized, and Preneoplastic/Neoplastic Liver.|
|Author||Chang, L. W. ; Pereira, M. A. ; Klaunig, J. E. ;|
|CORP Author||Health Effects Research Lab., Research Triangle Park, NC. ;Medical Coll. of Ohio at Toledo.|
|Additional Subjects||Halogen organic compounds ; Toxicity ; Environmental surveys ; Bioassay ; Biochemistry ; Laboratory animals ; Risk ; Metabolism ; Rats ; Exposure ; Hazardous materials ; Cultures(Biology) ; Chloroform ; Liver neoplasms ; Reprints ; Toxic substances ; Environmental health ; Carcinogenesis ; Ethane/dibromo ; Ethane/dichloro ; Ethane/trichloro|
Six halogenated hydrocarbons: chloroform, 1,2-dibromoethane (1,2-DBE), 1,1-dichloroethane (1,1-DCE), 1,2-dichloroethane (1,2DCE), 1,1,1-trichloroethane (1,1,1-TCE) and 1,1,2-trichloroethane (1,1,2-TCE) were evaluated for their cytotoxicity in primary cultures of rat hepatocytes isolated from normal, partial hepatectomized and from preneoplastic/neoplastic rat liver. None of the six halogenated alkanes exhibited any difference in their cytotoxicity toward hepatocytes isolated from normal liver or from liver containing preneoplastic/neoplastic lesions induced by either procedure.