Record Display for the EPA National Library Catalog
RECORD NUMBER: 1215 OF 1234Main Title | VEGF in Development [electronic resource] / | ||||
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Type | EBOOK | ||||
Author | Ruhrberg, Christiana. | ||||
Publisher | Springer New York, | ||||
Year Published | 2008 | ||||
Call Number | QD415-436 | ||||
ISBN | 9780387786322 | ||||
Subjects | Life sciences ; Biochemistry | ||||
Internet Access |
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Collation | online resource. | ||||
Notes | Due to license restrictions, this resource is available to EPA employees and authorized contractors only |
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Contents Notes | The Biology of Vascular Endothelial Cell Growth Factor Isoforms -- VEGF Receptor Signalling in Vertebrate Development -- VEGF Gene Regulation -- Embryonic Vasculogenesis and Hematopoietic Specification -- Role of VEGF in Organogenesis -- VEGF and Endothelial Guidance in Angiogenic Sprouting -- Vascular and Nonvascular Roles of VEGF in Bone Development -- VEGF in the Nervous System. his book is devoted to vascular endothelial growth factor A (VEGF his book is devoted to vascular endothelial growth factor A (VEGF or VEGFA), a secreted signalling protein of great significance for or VEGFA), a secreted signalling protein of great significance for T development and disease in vertebrates. VEGFAcontrols the prolifTdevelopment and disease in vertebrates. VEGFA controls the prol- eration, eration, migration migration, , specialisatio specialisation n and and surviva survival l of vascula ofvascular r endothelia endothelial l cells, cells, and and iit t isis therefor therefore e essentia essential l for th for e establishmen the establishment t of a functiona ofa functional l blood vesse blood l vessel circuit. circuit. IIn n addition addition, , VEGF VEGFA A is emergin is emerging g as a versatil as a versatile e patternin patterning g factor fofactor r for several several non endothelia non-endothelial l celcell l type types s in vertebrates in vertebrates. . ThusThus, , it playit s a centra plays al rol central e role during organ development at multiple levels, including blood vessel growth, duringorgan developmentat multiple levels, including blood vessel growth, vessel-mediated vessel mediated orga organ n inductio induction n andand tissutissue e differentiation differentiation. . The The discover discovery y ofof non endothelia non-endothelial l rolesroles for VEGF for VEGFA A initiallinitially y came ascarne a as a surprise. surprise. |