Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Modulation of Protein Stability in Cancer Therapy [electronic resource] /
Author Rubin, Eric.
Other Authors
Author Title of a Work
Sakamoto, Kathleen.
Publisher Springer US,
Year Published 2009
Call Number RC261-271
ISBN 9780387691473
Subjects Medicine. ; Oncology. ; Human genetics. ; Immunology. ; Microbiology. ; Biochemistry.
Internet Access
Description Access URL
Collation online resource.
Due to license restrictions, this resource is available to EPA employees and authorized contractors only
Contents Notes
Ubiquitin Ligases and Cancer -- The 26S Proteasome as a Therapeutic Target in Cancer: Beyond Protease Inhibitors? -- Targeting HAUSP: Killing Two Birds with One Stone -- Modulation of Protein Stability: Targeting the VHL Pathway -- Interrelationship of the Fanconi Anemia/BRCA Pathway -- Targeting the Sumoylation Pathway -- Proteasome Inhibitors -- Targeting Deubiquitinating Enzymes -- Proteolysis Targeting Chimeric Molecules. This book contains chapters written by experts in the field of the ubiquitin proteasome system and cancer. The authors have summarized current information on ubiquitin ligases and proteasomes as potential targets for cancer therapy. Topics covered in the book include an overview of ubiquitin ligases, deubiquitinating enzymes, and the proteasome. Specific diseases resulting from deregulated ubiquitin ligases, such as Von-Hippel-Lindau disease and Fanconi anemia are also discussed. Finally, novel approaches and drugs to target proteins involved in sumoylation, ubiquitination, and degradation are described.