||Health Assessment for 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) and Related Compounds. Chapter 6. Carcinogenicity of TCDD in Animals.
Lucier, G. ;
||Syracuse Research Corp., NY. ;National Inst. of Environmental Health Sciences, Research Triangle Park, NC.;Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.
||EPA-68-C0-0043; EPA/600/AP-92/001F ; OHEA-I-486-VOL-6
Aryl hydrocarbon receptors ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
Tumor incidence data in experimental animals were available in 1988 to demonstrate that TCDD is a carcinogen at multiple sites in rats and mice. Since 1988, TCDD has been shown to be a carcinogen in hamsters and some of the tumor incidence data in rat liver has been reevaluated. The chapter discusses approaches to risk assessment and recent advances on mechanisms of tumor promotion and dose-response relationships for biochemical and biological events relevant to the carcinogenic actions of dioxin.