Record Display for the EPA National Library Catalog

RECORD NUMBER: 522 OF 1241

OLS Field Name OLS Field Data
Main Title Glycans in Diseases and Therapeutics [electronic resource] /
Type EBOOK
Author Pavão, Mauro S.G.
Publisher Springer Berlin Heidelberg,
Year Published 2011
Call Number QH573-671
ISBN 9783642168338
Subjects Life sciences. ; Human physiology. ; Medicine. ; Biochemistry. ; Cytology.
Internet Access
Description Access URL
http://dx.doi.org/10.1007/978-3-642-16833-8
Collation XII, 188 p. online resource.
Notes
Due to license restrictions, this resource is available to EPA employees and authorized contractors only
Contents Notes
Heparan Sulfate Proteoglycan in Inflammation and Angiogenesis -- Heparan Sulfate Proteoglycans in Infection -- Glycans in cancer -- Glycosaminoglycans in atherosclerosis and thrombosis -- Glycans in Embryonic Stem Cells -- Heparan sulfate proteoglycans in cancer progression and therapy -- Structure and biological activities of glycosaminoglycan analogs from marine invertebrates: new therapeutic agents?. Initially believed to be inactive molecules, glycans are now considered essential for life, both under normal and pathological conditions. This volume of the series "Biology of Extracellular Matrix" reviews the most recent findings on the role of glycans in the development of diseases and the possible therapeutic use of this class of molecules. It shows how the interaction of glycans with growth factors, growth factor binding proteins, extracellular proteases, protease inhibitors, chemokines, morphogens, and adhesive proteins regulates inflammation, infection, cancer, atherosclerosis, thrombosis and embryonic stem cell biology. Furthermore, an extensive survey about the structure and pharmacological effects of unique marine glycosaminoglycans is discussed as well as the possibility of using these glycans as therapeutic agents. The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology. The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology.