Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Utility of Controlled Human Exposure Studies for Assessing the Health Effects of Complex Mixtures and Indoor Air Pollutants.
Author McDonnell, W. F. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Clinical Research Branch.
Publisher Dec 93
Year Published 1993
Report Number EPA/600/J-94/338;
Stock Number PB94-202066
Additional Subjects Indoor air pollution ; Test chambers ; Environmental health ; Human experimentation ; Biological effects ; Exposure ; Dose-response relationships ; Biological markers ; Mixtures ; Binary systems(Materials) ; Outcome measures ; Quality assurance ; Clinical protocols ; Research projects ; Air pollution ; Assessments ; Reprints ; Complex mixtures ; Exposure chambers
Library Call Number Additional Info Location Last
NTIS  PB94-202066 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 11/11/1994
Collation 7p
The study of health effects induced by exposure to mixtures of pollutants is a complex task. The purpose of this paper is to identify areas of research in which the conduct of chamber studies may contribute to better understanding of the health effects of exposure to indoor air and other mixtures. The strengths and weaknesses of clinical studies in general are reviewed as well as examples from the literature of approaches which have been utilized. It is concluded that chamber studies play an important role alongside epidemiologic and animal toxicologic studies in such research. The chamber studies are powerful in assessing acute, reversible effects from short duration exposures in the species of interest.