Record Display for the EPA National Library Catalog

RECORD NUMBER: 3 OF 3

Main Title

Support: Letter from (Confidential) to USEPA reporting Results of an Approximate Lethal Dose Study in Mice with (Confidential), a Substituted Benzoheterocycle, dated 11/03/1993. (Sanitized).

CORP Author

; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.

Year Published

1993

Report Number

8EHQ-1193-9022S

Stock Number

OTS0538519-1

Additional Subjects

Toxicology ; Health effects ; Toxic substances ; Substituted benzoheterocycle ; Mice ; Gavage

Holdings

Library	Call Number	Additional Info	Location	Last Modified	Checkout Status
NTIS	OTS0538519-1	Some EPA libraries have a fiche copy filed under the call number shown.		07/26/2022

Collation

Abstract

On April 12, 1993, we reported the results of an approximate lethal dose study in mice with this compound. This letter is to inform you of the results of a preliminary pharmacokinetic screen in rats. The test material was administered once by gavage to male rats at a dose level of 25 mg/kg. All rats survived. However, at 24 and 48 hours post dose, several rats exhibited clinical signs suggestive of central nervous system involvement, including splayed limbs, imbalance, abnormal gait and impaired locomotion. No formal report will be written for this study.