Record Display for the EPA National Library Catalog

RECORD NUMBER: 147 OF 1030

OLS Field Name OLS Field Data
Main Title Blockade of alpha-1 Adrenergic Receptor Inhibits Hepatic DNA Synthesis Stimulated by Tumor Promoters.
Author Tsai, W. H. ; Cruise, J. L. ; Michalopoulos, G. K. ;
CORP Author Duke Univ. Medical Center, Durham, NC. ;College of St. Thomas, St. Paul, MN.;Health Effects Research Lab., Research Triangle Park, NC.;National Institutes of Health, Bethesda, MD.
Publisher c1989
Year Published 1989
Report Number EPA-R-814344 ;NIH-CA43632; EPA/600/J-89/201;
Stock Number PB90-147778
Additional Subjects Deoxyribonucleic acids ; Carcinogens ; Liver ; Biosynthesis ; Cells(Biology) ; Rats ; Phenobarbital ; Reprints ; Adrenergic alpha receptor blockaders ; Prazosin ; Organ weight ; Ciprofibrate ; Benzene hexachloride
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB90-147778 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/15/1990
Collation 8p
Abstract
Studies with regenerating liver and hepatocyte cultures have shown that the alpha-1 adrenergic receptor (A1AR) is involved in the early events which transmit a mitogenic signal to hepatocytes after 2/3 partial hepatectomy. In the study, the role of A1AR in DNA synthesis associated with the augmentative hyperplasia stimulated by the xenobiotic hepatic tumor promoters phenobarbital (PB) and alpha-hexachlorocyclohexane (alpha-HCH), and the peroxisome proliferator ciprofibrate was investigated. Male F344 rats were treated with each of the three xenobiotics to stimulate hepatic DNA synthesis. These studies suggest that A1AR is involved in generating the mitogenic signal leading to hepatic DNA synthesis induced by xenobiotic hepatic tumor promoters phenobarbital and alpha-HCH. A1AR is not involved in the mitogenic pathway generated by the peroxisome proliferator ciprofibrate.