||Hexachlorobenzene-Induced Renal Maldevelopment in CD-1 Mice and CD Rats.
Andrews, J. E. ;
Courtney, K. D. ;
||Health Effects Research Lab., Research Triangle Park, NC.
Urologic diseases ;
Environmental surveys ;
Pregnancy complications ;
Laboratory animals ;
Foreign technology ;
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Enlarged kidneys and hydronephroses were observed in day 15 postpartum (pp) CD-1 mouse pups from dams treated with 10 or 50 mg HCB/kg body weight on days 6-16 of gestation. Additional studies showed that enlarged kidneys occurred as well on days 1 and 20 pp. CD rat pups from dams exposed to 10 mg HCB/kg body weight on days 15-20 of gestation had enlarged kidneys on postpartum day but not on days 10 or 20. In the CD rat, there was a significant increase in the kidney-to-body-weight ratio and the liver-to-body-weight ratio for the HCB exposed pups at all three time periods. Pre- and post-natal exposure to HCB resulted in renal maldevelopment in CD-1 mice and CD rat in terms of enlarged kidneys and hydronephrosis.