Record Display for the EPA National Library Catalog

RECORD NUMBER: 5 OF 15

OLS Field Name OLS Field Data
Main Title DNA Adduct Formation by 7,12-Dimethylbenz(a)anthracene and its Noncarcinogenic 2-Fluoro Analogue in female Sprague-Dawley Rats.
Author Daniel, F. B. ; Joyce, N. J. ;
CORP Author Health Effects Research Lab., Cincinnati, OH.
Year Published 1982
Report Number EPA-600/J-83-008; EPA-R-807895;
Stock Number PB83-194548
Additional Subjects Deoxyribonucleic acids ; Females ; Rats ; Laboratory animals ; Reprints ; Polycyclic aromatic hydrocarbons ; Benzanthracene/dimethyl
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB83-194548 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 10p
Abstract
The potent polycyclic aromatic hydrocarbon 7.2 dimethylbenz(a)anthracene (DMBA) bound to the DNA of numerous organs of the female outbred Sprague-Dawley rat after iv administration under a regimen known to produce a high yield of mammary adenocarcinomas. The maximum DNA binding levels observed following iv administration of 5 mg DMBA range from approximately 12 micromol hydrocarbon/mol deoxyribonucleic for the liver to approximately 5 micromol hydrocarbon/mol deoxyribonucleotide for the mammary gland, the target tissue.