Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Application and assessment of neurobehavioral methods in rats /
Author Moser, Virginia C.
Other Authors
Author Title of a Work
Moser, Virginia C.
CORP Author NSI Technology Services Corp., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory,
Year Published 1989
Report Number EPA/600/D-89/139
Stock Number PB90-113192
Additional Subjects Animal behavior ; Graphs(Charts) ; Tables(Data) ; Motor activity ; Neurotoxins ; Tests ; Risk assessment ; Dose-response relationships
Library Call Number Additional Info Location Last
NTIS  PB90-113192 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 01/01/1988
Collation 29 pages ; 28 cm
The majority of chemicals present in the environment have not received adequate testing to determine their neurotoxic potential. Thus, the US EPA has prepared guidelines for neurotoxicity testing for both new and existing chemicals. Based on these guidelines, a core battery of tests to assess the behavioral and neurological integrity of laboratory rats was developed for use in the primary screening of chemicals. The study systematically applies the FOB and MA to characterize known neurotoxicants and to assess sensitivity, reliability, selectivity, and specificity of the tests. The FOB includes home-cage and open-field observations, and neuromuscular, sensorimotor, and physiological measures. MA is measured in an automated photocell device (figure-eight maze). The tests have been demonstrated to be sensitive to a variety of neurotoxicants, and profiles of effects can be established to distinguish between them. The data provide important information on the feasibility and interpretation of functional evaluations in the hazard identification of neurotoxic chemicals.
Includes bibliographical references. "EPA/600/D-89/139"--Cover. "Presented at the Proceedings of the Third International Symposium on Neurobehavioral Methods in Occupational and Environmental Health." Microfiche.