Section 303(d) of the federal Clean Water Act (CWA) and the U.S. Environmental Protection Agency's (EPA) implementing regulations direct each State to identify and list waters, known as water quality limited segments (WQLSs), in which currently required controls of a specified substance are inadequate to achieve water quality standards. For each WQLS, the State is to either establish a Total Maximum Daily Load (TMDL) of the specified substance that the waterbody can receive without violating water quality standards, or demonstrate that water quality standards are being met (CFR 2006c). Nanticoke River (basin number 02130305) was first identified on the 1998 303(d) List submitted to U.S. Environmental Protection Agency (EPA) by the Maryland Department of the Environment (MDE). The designated uses in Nanticoke River were listed as impaired by fecal coliform in tidal portions of the basin (1998), bacteria at two public beaches (1998, 2006), and impacts to biological communities in the tidal and non-tidal portions (2004). In 2004, the fecal coliform listing was refined by identifying one restricted shellfish harvesting area within the basin (MDE 2006). The assessment unit listing code for this area in Marylands 303(d) List is MD-NANMH-NANTICOKE-RIVER. This document, upon EPA approval, establishes TMDLs of fecal coliform for the one restricted shellfish harvesting area in the Nanticoke River basin: the Nanticoke River mainstem. The listings for impacts to biological communities and bacteria at two public beaches within the Nanticoke River basin will be addressed at a future date.