Record Display for the EPA National Library Catalog

RECORD NUMBER: 21 OF 52

OLS Field Name OLS Field Data
Main Title Effects of Exposure to Peroxyacetyl Nitrate on Susceptibility to Acute and Chronic Bacterial Infection.
Author Thomas, Gail B. ; Fenters, James D. ; Ehrlich, R. ; Gardner, D. E. ;
CORP Author IIT Research Inst., Chicago, IL.;Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div.
Year Published 1981
Report Number EPA-68-02-1273; EPA-600/J-81-603;
Stock Number PB83-140822
Additional Subjects Air pollution ; Bacterial diseases ; Aerosols ; Nitrogen organic compounds ; Susceptibility(Physiology) ; Mice ; Laboratory animals ; Reprints ; Peroxyacetyl nitrate ; Streptococcus pyogenes ; Photochemical oxidants
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB83-140822 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 18p
Abstract
A significant increase in mortality due to acute respiratory pneumonia caused by inhalation of Streptococcus pyogenes aerosol was seen after a single 3-h exposure of mice to 14.8-28.4 mg/cu.m. peroxyacetyl nitrate (PAN). The excess mortality ranged from 8 to 39% and the decrease in survival time from 2.4 to 7.9 d. A single exposure to 25.0 mg/cu.m. PAN resulted in a significant increase in total number of cells lavaged from the lungs but somewhat decreased levels of ATP in alveolar macrophages. PAN did not produce any marked changes in a chronic respiratory infection in mice as measured by Mycobacterium tuberculosis lung titers.