Record Display for the EPA National Library Catalog

RECORD NUMBER: 24 OF 1215

OLS Field Name OLS Field Data
Main Title Altered Maternal Zinc Metabolism Following Exposure to Diverse Developmental Toxicants (Revised).
Author Taubeneck, M. W. ; Daston, G. P. ; Rogers, J. M. ; Keen, C. L. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;California Univ., Davis. ;Procter and Gamble Co., Cincinnati, OH. Miami Valley Labs.;National Institutes of Health, Bethesda, MD.;Department of Agriculture, Washington, DC.
Publisher c1994
Year Published 1994
Report Number EPA/600/J-94/400; NIH-HD01743;
Stock Number PB95-126447
Additional Subjects Zinc ; Metabolism ; Toxicity ; Rats ; Maternal exposure ; Nutrition ; Biological effects ; Maternal-fetal exchange ; Dose-response relationships ; Food consumption ; Statistical analysis ; Urethane ; Arsenic ; Alcohols ; Melphalan ; Metallothionein ; Reprints ; Alpha-hederin ; Acute phase response
Holdings
Library Call Number Additional Info Location Last
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Status
NTIS  PB95-126447 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/06/1995
Collation 20p
Abstract
The hypothesis that hepatic metallothionein (MT) induction in the pregnant animal results in a zinc (Zn) deficiency in the embryo was tested by treating pregnant rats with alpha-hederin, reported to induce MT in rat liver. Morphological development was assessed in term fetuses. A single dose of alpha-hederin, of 3-300 micromodes/kg, caused a dosage-related increase in maternal hepatic MT. These data support the hypothesis that systematic changes in Zn status, brought about by induction of hepatic MT, maybe a mechanism for maternally-mediated abnormal development.